Semax is a synthetically modified analog of ACTH (4-10) that demonstrates nootropic and neuroprotective activity. It was originally formulated and studied in Russia for its benefits on brain health and cognitive function, and is still under active study for these benefits and as a therapeutic tool in neurological diseases.
Availability: In-Stock
Semax, or ACTH (4-7) Pro-Gly-Pro, is a research peptide offering various potential neuroprotective and cognitive benefits.
It is a heptapeptide made of 4 amino acids (Met-Glu-His-Phe) at the N-terminus taken from ACTH(4-7) and a Pro-Gly-Pro fragment at the C-terminus [1].
This unique chemical structure was engineered to let Semax directly cross the blood-brain barrier (BBB) and exert its therapeutic effects [2, 3].
Semax was first developed in the former Soviet Union in the late 1980s. The research peptide is believed to offer potential therapeutic benefits for individuals suffering from dementia, stroke, general cognitive decline, and other cognitive diseases [4].
The latest studies show that Semax likely works by activating dopaminergic and serotonergic brain systems, increasing levels of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), and protecting neurons against oxidative stress [5, 6, 7, 8, 9].
In addition to its regular form, Semax is also available as an acetylated and amidated formulation, known as N-Acetyl Semax Amidate. These modifications are thought to improve the peptide’s stability and potency [10].
Before buying Semax or N-Acetyl Semax Amidate for research purposes, it’s important to consider this peptide’s benefits, side effects, contraindications, and legal status.
Our team of experts addresses all of these considerations below before revealing our top recommendations for where researchers can buy Semax online.
Semax is a sought-after peptide for researchers studying rehabilitation protocols for test subjects suffering from various neurological disorders.
Here are a few of the potential benefits of this peptide:
Let’s take a closer look at each of these benefit categories.
The available pre-clinical and clinical data show that Semax has the following potential benefits for overall brain health and cognitive performance [4, 11, 12, 13]:
Semax is suggested to provide benefits for mood regulation, including anxiolytic and antidepressant effects in laboratory animal experiments [14, 15].
Here are the most notable findings in regard to Semax’s mood regulation potential:
Due to its unique chemical structure and mechanism of action, Semax appears to offer neuroprotective properties in a variety of neurological conditions, including:
According to these clinical and pre-clinical studies, Semax protects the brain from further damage by increasing tolerance to hypoxia, reducing inflammation, and upregulating growth factors that may benefit nerve cell regeneration and neuroplasticity.
Semax potentially offers benefits unrelated to improvements in neurological function, such as an apparent gastroprotective effect [22].
One study in patients with refractory peptic ulcers reported anti-ulcer effects following application of intranasal 1% Semax at a dose of 2-4 drops three times a day for ten days. The peptide was well-tolerated and led to ulcer healing in 89.5% of patients receiving the peptide vs. 30.8% in the control group [22].
More quality studies are needed to explore the potential benefits of Semax outside its application as a nootropic and/or neuroprotective agent.
Semax has been studied since the late 1980s with noteworthy results for a variety of neurological conditions. It is currently approved for use in Russia and Ukraine as a safe neuroprotective and cognitive-enhancing agent in ischemic brain stroke, encephalopathy, optic nerve atrophy, and other neurological indications [23].
Published clinical research also confirms the peptide’s safety and does not report any specific side effects related to Semax in doses ranging from 600mcg-12000mcg when applied intranasally [4, 16, 17, 20, 21, 24].
One of the longest studies to date involved 30 days of intranasal application as a 0.1% solution in 36 glaucoma patients and also did not report any side effects [25].
Kaplan et al. (1996) noted that a single dose of 16mcg/kg of body weight may induce some anxiogenic effects on test subjects related to its nootropic and stimulating benefits. However, other researchers have not confirmed these concerns [11].
In contrast, clinical research is scarce regarding the administration of injectable Semax. Nevertheless, the peptide has not demonstrated any adverse effects following its administration via injection in laboratory animal models.
Qualified professionals planning to include the injectable Semax in their trials should note that safety data still remains scarce.
To minimize potential risks, researchers may consider adhering to the following safety tips when administering Semax in experimental settings:
By following these steps, in addition to selecting a reliable peptide vendor and establishing a judicious dosing protocol, researchers will maximize the odds of success.
Semax is readily accessible for online purchase by peptide researchers and laboratory professionals.
As an increasing number of vendors now offer Semax and various other research peptides for sale, it is crucial for researchers to thoroughly evaluate their options before proceeding with a purchase.
To mitigate the risk of obtaining peptides of subpar purity, we strongly advise purchasing exclusively from vendors who source their peptides from accredited facilities and subject all compounds to third-party purity verification.
Here are our top recommendations for both Semax nasal spray and Semax powder for injection.
We endorse Research Peptide as a reputable source of Semax nasal spray. The vendor excels across the board for the following reasons:
Research Peptide also offers N-Acetyl Semax Amidate nasal spray for researchers interested in procuring the modified version.
Research Peptide has been long recognized as a reliable provider of research-grade nootropics and other peptides, presenting numerous benefits, such as:
Researchers may be wondering how to administer Semax. There are two main methods to administer the peptide as a reference material in research settings:
Below, researchers can take a closer look at each option.
Semax was originally designed for intranasal administration. Indeed, this administration method has notable advantages: it is easy to administer, painless, and will not cause injection-related side effects.
Here are the steps for administering Semax nasal spray:
For more information, make sure to check out our dedicated article on Semax nasal spray handling and storage.
Subcutaneous injections are another viable administration route of Semax for research purposes.
It’s important to note that injectable Semax for research is usually available as a lyophilized powder that must be reconstituted before use with a sterile solvent such as bacteriostatic water.
Once reconstituted, here are the main steps that researchers must follow when administering the research peptide:
Ensure proper hygiene, follow sterile procedures, and rotate injection sites for safety and effectiveness when administering subcutaneous injections of Semax.
When considering the choice between purchasing Semax nasal spray or injections for research purposes, professionals need to account for various factors to determine the better option. These factors include the research objective, subject compliance, and cost-effectiveness.
Leading researchers have successfully utilized both options in their studies, so it is essential to understand the pros and cons of each before making a final decision on the route of administration.
In terms of effectiveness, the subcutaneous route of administration offers advantages such as precise and reliable dosing, with fewer factors that may interfere with absorption and bioavailability.
Therefore, Semax injections are preferred for researchers looking to ensure consistent absorption and bioavailability among test subjects [26].
On the other hand, laboratory animal studies comparing intranasal vs. injectable Semax report that the nasal route of administration may be more potent for improving learning capabilities [27].
Regarding the form of administration, Semax nasal spray offers advantages in terms of ease. It is easy to administer and tolerable for most test subjects.
By contrast, some test subjects may find Semax injections painful, unpleasant, or poorly tolerated due to reactions at the injection site, leading to reduced compliance. If ease of administration is crucial, researchers are encouraged to use Semax nasal spray in their studies.
Considering side effects, intranasal Semax has been more extensively researched and shown generally well-tolerated. Injectable Semax has been applied primarily in laboratory animal studies [18, 25, 27].
Notably, Semax administration via subcutaneous injections carries a risk of specific side effects such as pain, skin irritation, redness, bleeding, swelling, and infections. More research is necessary to evaluate the safety of Semax injections compared to intranasal Semax.
Cost and accessibility are additional factors to consider. The cost of Semax injectable and nasal spray products can vary depending on the source. For example, Semax nasal spray is available as a 30mg spray bottle from Research Peptide Nootropics for $76.99.
A 30mg/10ml Semax nasal spray delivers 300mcg per pump. Thus, one 30mg spray bottle will be sufficient for 50 days if administered at two pumps/daily, 33 days at three pumps/daily, and 25 days at four pumps/daily.
On the other hand, aliquot Semax in the form of a 30mg vial from this research peptides vendor cost $76.48.
While both forms are available at an affordable price from reliable online vendors, Semax injections are priced lower when accounting for the subcutaneous route’s superior bioavailability.
Semax was first developed in the 1980s and today remains one of the more promising research peptides for cognitive enhancement and neuroprotection.
Researchers must be fully aware of the peptide’s mechanisms, potential side effects, and dosing recommendations before embarking on a Semax experiment.
There are a number of online peptide vendors offering Semax for sale, available in either nasal spray or injectable format.
Research Peptide Nootropics stocks research-grade Semax nasal spray.
Disclaimer: Peptideinfo.net contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Peptideinfo.net makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptideinfo.net makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.
To the extent that Peptideinfo.net references a product that is also a prescription medication, Peptideinfo.net does not does not offer medical diagnosis or treatment advice. The contents of Peptideinfo.net are intended exclusively for qualified researchers. Any individual seeking any advice on any prescription medication, or any disease or condition, is advised to refrain from using this site and consult their healthcare provider. Statements regarding products presented on Peptideinfo.net are the opinions of the individuals making them and are not necessarily the same as those of Peptideinfo.net.
© Peptideinfo.net. All rights reserved.
