Epithalon is a tetrapeptide isolate derived from epithalamin, a crude polypeptide extract of bovine pineal glands. Developed in the 1980s by Professor Vladimir Khavinson, epithalon induces telomere elongation, thereby delaying aging of the reproductive and immune systems and increasing the lifespan of organisms. Used clinically in Russia, epithalon is heavily studied around the world for its demonstrated anti-aging, sleep-promoting, anti-cancer, and disease-fighting properties.
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Epithalon is a synthetic version of epithalamin, a naturally occurring tetrapeptide found in the bovine pineal glands. Also known as epitalon or epithalone, it was discovered in the late 1980s by Prof. Vladimir Khavinson, who now heads the Saint Petersburg Institute of Bioregulation and Gerontology [1].
Like epithalamin, epithalon is also a tetrapeptide that comprises four amino acids. It is believed to stimulate and elongate telomeres in human somatic cells, helping them maintain proper length. Epithalon’s ability to upregulate telomerase activity has numerous effects, including life extension, anti-aging properties, and inhibition of tumorigenesis [2, 3].
Epithalon has been found to suppress the CCl11 and HMGB1 genes and increase the lifespan of cell cultures and animal test subjects [4]. Further, the peptide has also been found to exert antioxidant effects, while inhibiting carcinogenic receptor expression, giving it anti-tumor effects in breast and colorectal cancer [5, 6].
Epithalon regulates biomolecules that play important roles in the inflammation process including cytokines and C-reactive protein. This suggests that it may be beneficial in treating conditions such as rheumatoid arthritis and ulcerative colitis [7].
Lastly, epithalon plays a significant role in the endocrine system by increasing levels of endogenous hormones that naturally diminish with age, such as melatonin (which helps regulate the sleep cycle), and gonadotropic hormones (FSG, LG, prolactin), which play a role in reproductive functions [8].
Epithalon is a research chemical and is therefore sold for in vitro testing and laboratory experimentation only. It is not approved by the United States Food and Drug Administration nor by any of its international regulatory counterparts. Researchers interested in studying epithalon may note that it has been observed to offer the following benefits in past studies and trials.
As telomeres shorten with age and epithalon induces telomerase activity and elongates telomeres, there is strong research interest in epithalon from an anti-aging standpoint:
As noted, epithalon can increase levels of melatonin, which is strongly involved in regulating the sleep cycle, thus leading to research interest in the sleep-promoting effect of epithalon [8].
A 2007 clinical trial conducted in Russia found that epithalon can normalize the hormone circadian rhythm in elderly test subjects and increase nighttime levels of melatonin in subjects with pineal gland functional insufficiency [13]. These findings prompted researchers to conclude that epithalon may help increase the quality of life for elderly patients by improving sleep quality.
Epithalon has antioxidant activity that helps regulate levels of cytokines and C-reactive protein [5, 7]. This has generated strong research interest in epithalon as a potential treatment for a variety of inflammatory ailments including arthritis and ulcerative colitis.
Breast cancer and colorectal cancer studies have shown that epithalon exhibits strong anti-tumor effects and inhibits the expression of carcinogenic receptors [6]. A research paper published in 1997 found that epithalon treatment decreased the size of tumors in test subjects with ovarian, uterine, and cervical cancer while helping to restore cellular immunity [14].
This brief summary of epithalon benefits should provide researchers with a useful starting point for identifying key areas where further research may be warranted.
According to a 15-year follow-up study on patients who had received up to six courses of epithalamin treatment over a period of three years, researchers were not able to identify any major side effects or adverse events caused by the peptide [12]. This is consistent with the published epithalon research to date.
As with the subcutaneous administration of any peptide, the subject may experience minor, injection-related side effects such as swelling and redness at the injection site. Mild nausea has also been reported in subjects who are administered doses in excess of 1mg.
Epithalon has not undergone any long-term safety studies, for which reason we cannot draw any definitive conclusions related to its safety. Researchers interested in investigating epithalon’s safety profile should note that the peptide has not been formally reviewed by the United States Food and Drug Administration, nor by any of its international regulatory counterparts.
As noted, however, the peptide has exhibited minor to no side effects when administered to both animal subjects and humans, across a variety of research settings and dosages. Notably, based on the results of the above-cited 15-year follow-up study, concluded in 2011, epithalamin-treatment patients had “significantly lower mortality” compared to the control group [12].
In summary, despite the lack of formal long-term safety data on epithalon, we do not note any safety issues associated with the peptide.
Epithalon is sold exclusively for research purposes and no dosing protocol has been universally agreed upon as safe and effective for test subjects. A number of dosage protocols appear in the epithalamin and epithalon studies and trials performed to date, the most notable of which has been the Khavinson protocol (or, “Russian protocol”) for anti-aging and longevity [1].
The Khavinson protocol calls for a total course of 100mg of epithalon, administered as follows:
Researchers curious about where to buy epithalon online may be overwhelmed by the number of peptide vendors to choose from.
To assist researchers, our team has placed small test orders with multiple online vendors and rated them according to factors like:
So, what’s our No. 1 recommendation?
At Peptideinfo.net, we recommend choosing Research Peptide when sourcing epithalon for research.
Their peptides are independently tested for quality, and they also offer excellent service and convenient shipping options. Additionally, they have been recognized for their outstanding business practices.
Here’s more about why we like Research Peptide:
Additionally, Research Peptide also offers Epithalon capsules for research.
Last but not least…
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Epithalon is reconstituted by injecting bacteriostatic water into the peptide vial and swilling the solution until the epithalon powder is fully dissolved.
Epithalon is most commonly injected subcutaneously, approximately two inches to either side of the test subject’s belly button area.
Based on the Khavinson protocol, epithalon may be administered subcutaneously at a daily dose of 10mg for 10 days. This course may be administered twice annually, with at least a four month break in between courses.
Researchers interested in where to buy epithalon should have no issues obtaining this research chemical from our preferred vendor for their next experiment. Our summary of this peptide’s benefits, side effects, and dosages has helped highlight plenty of possible directions for future work to take including anti-aging, sleep, antioxidant, and anti-tumor research.
Researchers looking to buy epithalon are advised to place their orders with the leading supplier of US-produced peptides.
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