MOTS-c is a recently discovered peptide that derives from a small protein encoded in the mitochondrial DNA and is involved in regulating metabolism and energy homeostasis. It has shown promising effects in preclinical studies, which have demonstrated its ability to improve metabolic health, enhance physical performance, and mitigate age-related decline in animal models.
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MOTS-c, short for “mitochondrial open reading frame of the 12S rRNA-c,” is a small peptide derived from a specific region of the mitochondrial genome. Since its discovery, MOTS-c has garnered attention due to its potential role in regulating metabolism and age-related health [1].
Within cells, particularly in the mitochondria, which are the energy-producing organelles, MOTS-c is believed to function as a signaling molecule. It has been found to impact various aspects of cellular metabolism, insulin sensitivity, mitochondrial function, and potentially aging-related processes [2].
Research suggests that MOTS-c may have several beneficial effects, including improving glucose uptake and utilization, enhancing insulin sensitivity, promoting the formation of new mitochondria (mitochondrial biogenesis), and reducing oxidative stress.
These effects could potentially contribute to better metabolic health and improved cellular function, with implications for conditions such as diabetes, obesity, and age-related diseases. Although the exact mechanisms of action for MOTS-c are still under investigation, initial studies indicate that it may have regulatory effects on cellular metabolism and mitochondrial function [3].
Further research is necessary to fully comprehend its precise functions and explore potential therapeutic applications.
While research on MOTS-c is still in its early stages, several benefits and uses have been proposed based on initial findings.
In a study by Lee et al. (2015), mice receiving MOTS-c injections alongside a high-fat diet showed significant weight reduction compared to a group on a regular diet [2]. However, no weight reduction was observed as a result of administering MOTS-c to mice on the normal diet.
These findings suggest potential implications of MOTS-c for weight management, particularly in the context of a high-fat diet [2]. Further research, including clinical trials, is necessary to determine its effectiveness and safety in humans.
MOTS-c treatment in mice undergoing ovariectomy prevented obesity and insulin resistance by activating brown fat and reducing fat accumulation and inflammation.
These findings indicate the potential benefits of MOTS-c in mitigating metabolic changes in postmenopausal women. However, further research is needed to fully understand its therapeutic implications for postmenopausal metabolic dysfunction [4].
Aging is a complex process characterized by the deterioration of biological functions and reduced ability to handle metabolic stress. MOTS-c, a peptide, plays a role in healthy aging by enhancing mitochondrial fitness and physical capacity [5].
It increases NAD+ levels, influences metabolic pathways, and improves physical performance in mice [5]. These findings suggest that MOTS-c could be a therapeutic target for promoting healthy aging and preventing age-related diseases, but more research is needed to understand its mechanisms and potential applications in humans.
During exercise, mitochondria are vital for supporting skeletal muscle function and transmitting exercise-induced signals. MOTS-c, in combination with exercise training, has been shown to enhance the expression of the PGC-1α gene, which governs mitochondrial biogenesis and energy metabolism [6].
In mice, MOTS-c treatment activates skeletal muscle AMPK, a key exercise regulator, by increasing AICAR (an AMPK agonist) and GLUT4 levels. Similarly, regular aerobic exercise increases PGC-1α, GLUT4, and AMPK phosphorylation in mice [7].
MOTS-c acts on exercise-sensitive signaling intermediates like AMPK, SIRT1, and PGC-1α, promoting fatty acid oxidation and mitochondrial biogenesis to enhance muscle metabolic capacity [6].
MOTS-c and exercise exhibit overlapping effects on genes related to angiogenesis, inflammation, and apoptosis, potentially reducing the risk of metabolic disorders and cardiovascular complications [8].
Further research is required to fully grasp the mechanisms and therapeutic applications of MOTS-c and exercise.
In a study by Quing Quin et al. (2018), patients with endothelial dysfunction (ED) had lower levels of MOTS-c in their plasma compared to those with normal endothelial function [9].
Another study by Zhong et al. (2022) showed that MOTS-c peptide administration mitigated cardiac dysfunction and remodeling in a heart failure mouse model, reducing inflammation and activating the AMPK pathway [10].
To date, no significant adverse side effects have been reported in studies investigating MOTS-c. Animal studies and in vitro experiments have shown positive effects without apparent toxicity. However, further research is needed to assess the long-term safety and potential side effects in humans.
A clinical study conducted by CohBar on a MOTS-c analog called CB4211 in individuals with nonalcoholic steatohepatitis (NASH) and obesity demonstrated good tolerability and safety, with no significant adverse effects reported [11]. These findings contribute to our understanding of the safety profile and potential therapeutic uses of MOTS-c analogs.
As an injectable peptide, MOTS-c may have potential adverse effects, which can include:
It is important to be aware of these potential risks when considering MOTS-c injections.
MOTS-c dosing in mice has been investigated in a few studies. The dosing regimens can vary depending on the specific experimental design, the desired outcome, and the age and strain of the mice used. Here are a couple of examples:
The dosing of MOTS-c in humans is still being investigated, and there is currently no standardized dosing regimen established. MOTS-c is a relatively new discovery, and its translation into clinical applications is in the early stages of research.
Here is a sample reference dosing for MOTS-c regimen that researchers may use for weight loss:
The expert reviewers at Peptideinfo.net have scoured the net to bring the research community our top recommendation for reliably sourcing genuine MOTS-c online.
Our top recommended choice for purchasing research-grade MOTS-c is none other than Research Peptide.
Here’s a breakdown of why we love this vendor:
Given their world-class lab testing, competitive pricing, domestic production, fast shipping, and service, Research Peptide is a highly regarded choice for purchasing MOTS-c. Buy with confidence.
The vendor is also extending a 10% savings to first-time shoppers. To take advantage, enter this coupon code at checkout:
To calculate the total cost of the MOTS-c, we need to consider the dosage, frequency, duration of treatment and quantities and prices of the products.
The cost of MOTS-c from our recommended vendor is as follows:
Total MOTS-c Dosage: The total dosage required for the above weight loss protocol is 80mg for a study duration of eight weeks.
Therefore, the total cost of MOTS-c needed for the sample protocol is $799.92.
MOTS-c is typically administered through injections, either intraperitoneal (IP) or subcutaneous (SC), depending on the study protocol or clinical trial design.
To date, no significant adverse side effects have been reported in studies conducted on MOTS-c. However, individual responses may vary, and it is recommended to evaluate all risks before commencing MOTS-c experimentation.
Currently, MOTS-c is primarily being studied in preclinical and animal models. Further research, including clinical trials, is needed to evaluate its effectiveness and safety in humans. Where it is sold as a research chemical, MOTS-c is intended strictly for laboratory experimentation.
While MOTS-c shows promise in weight management, it is important to note that it is still under investigation.
MOTS-c has been implicated in promoting healthy aging by improving mitochondrial function and cellular metabolism. However, more research is needed to fully understand its role and potential as an anti-aging intervention in humans.
MOTS-c is a synthetic peptide derived from mitochondrial DNA. It is not naturally present in food sources nor commonly found in the human body.
The potential interactions of MOTS-c with other therapies or supplements are still being explored.
As well, all researchers must be equipped with the right tools to handle MOTS-c and other peptides.
In order to correctly prepare and store peptides, supplies including bacteriostatic water, alcohol swabs, and more should be available.
Overall, a research lab may need materials and supplies like these listed below and more:
For labs and researchers who do not have these materials, it is recommended to source from authorized vendors.
MOTS-c is a small peptide molecule that optimizes mitochondrial function, enhancing cellular energy production and metabolic health. It occurs naturally and has several benefits. MOTS-c exhibits potential in the treatment of obesity and diabetes, while also potentially slowing down the aging process and supporting muscle health and recovery.
If you’re looking to purchase MOTS-c, Research Peptide is a highly reliable source that offers this product. This vendor is a reputable supplier of research chemicals and is recognized for its commitment to quality and satisfaction.
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